The algorithms and data implemented in this program for the calculation/simulation of the burn-up behaviour are developed and tested with the greatest care, but are based on data and physical equations which for practical reasons contain theoretical assumptions as well as average values and approximations from empirical measurements.
Not every gun or component is the same! The components, from the chamber, barrel, case, bullet to the propellant powder vary from gun to gun and manufacturer and date of manufacture (lot). The results can therefore deviate greatly from the real conditions existing with them.
Compare the results with tested loading tables and/or manufacturer's recommendations. In case of doubt, e.g. if loading tables, manufacturer's specifications and simulation calculations all differ, you should have your hand-loaded ammunition tested by a institute!
As a reloader you act on your own responsibility!